Native Human Tissues
At Krishgen Biosystems, we offer a comprehensive range of Native Human Tissues, ethically sourced and of the highest quality, to support your cutting-edge research. In collaboration with our esteemed partners, Genoskin and Novabiosis, we provide diverse tissue types to meet your specific research needs, from live and functional skin models to frozen tissue samples spanning various organs and anatomical regions.
Available Tissue Types:
Live Human Skin Models:
- Genoskin: Specializes in providing live human skin platforms for reliable first-in-human testing. Their models contain real human skin maintained alive for up to 7 days post-surgery, allowing for comprehensive testing on all skin cell types and appendages simultaneously.
Fresh and Frozen Human Tissues:
- Novabiosis: Offers both fresh and frozen full-thickness human tissues, including liver, lung, intestine, pancreas, kidney, spleen, brain, eye, birthing tissues, and skin. Their focus on cryopreservation and viability optimization ensures researchers receive well-preserved tissues suitable for various applications.
Applications Include:
- In Vitro Modeling: Utilize native human tissues for accurate modeling in drug discovery, disease research, and personalized medicine.
- Disease Research: Study specific diseases in a controlled environment with relevant human tissue models.
- Therapeutic Development: Develop and test new therapies with enhanced precision and efficiency.
Benefits of Native Human Tissues:
- Ethical Sourcing: All tissues are obtained with proper consent and ethical considerations, ensuring responsible research practices.
- High-Quality Samples: Our partners provide tissues with intact structures and cellular compositions, enabling accurate in vitro modeling.
- Diverse Tissue Types: Access to a wide range of tissues allows researchers to select the most appropriate models for their studies.
Tissues Available
• Unparalleled In Vitro Models: Native human tissues offer the closest representation of human biology for in vitro research, leading to highly translatable results.
• Disease Modelling: Study specific diseases in a controlled environment with relevant human tissue models.
• Drug Discovery & Development: Evaluate potential drugs on human tissues for better prediction of efficacy and safety.
Our Principal Partners Provide
• Unmatched quality and ethical sourcing practices.
• Diverse tissue types to suit your specific research area.
• Expert support to guide your research journey.
Tissues Available
NativeSkin: NativeSkin models offer live human skin models made from donated biopsies. These models, kept alive in a special matrix, provide researchers with a predictive and efficient way to study human skin response, with various formats available to suit specific research needs.
HypoSkin: HypoSkin is the only live human skin model for studying the effects of under-the-skin injections. These patented models use donated biopsies with all three skin layers, kept alive for a realistic human response.
InflammaSkin: Genoskin’s InflammaSkin® model, a human T cell-driven skin inflammation model, utilizes NativeSkin® technology. This model allows researchers to evaluate both preventative and therapeutic treatments for psoriasis, including topical drugs and injectable biologics.
Fresh Full Thickness Skin: By providing fresh, full-thickness skin that retains its original structure and cellular makeup, Novabiosis enables researchers to create highly accurate in vitro models. This allows for the development and testing of new therapies with a higher degree of precision.
Frozen Full Thickness Skin: Novabiosis’ frozen full-thickness skin retains integrity and viability, enabling long-term storage and versatile research. From drug screening to skin physiology studies, these high-quality samples provide researchers with reliable and reproducible results.
Skeletal Muscle: Novabiosis provides ethically sourced skeletal muscle tissue, a valuable tool for studying muscle biology and disease. These tissues retain their natural structure and function, allowing researchers to accurately model muscle development, disease mechanisms, and potential therapies.
Frozen Tissues: Novabiosis’ diverse frozen tissue bank, spanning organs and anatomical regions, empowers researchers with a one-stop resource for various studies. From cancer biology to tissue regeneration, these ethically sourced, high-quality tissues offer the flexibility to tackle a multitude of research questions.
Adipose Tissue: Novabiosis offers high-quality adipose tissue samples, a valuable resource for researchers studying adipocyte biology and metabolic diseases like obesity and diabetes. These tissues allow investigation into energy homeostasis, hormone regulation, and inflammation, all critical areas for metabolic health research.
Want to learn more about these tissues? Reach out to our Product Manager.
Interested in learning more about protocols for various available applications?
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Scientific Validation in Terms of Skin Structure
Human skin structure is maintained for +7 days
Since it is real human skin, NativeSkin® has the same structure and composition as in vivo human skin. It presents a mature stratum corneum and normal skin barrier function and their integrity can be preserved for 7 days. After 7 days of culture, experimental data may show higher variability but NativeSkin® remains viable. Hematoxilin & Eosin staining shows mature stratum corneum, a dermal-epidermal junction that comprises the key features of the dermal-epidermal junction of real human skin, with a preserved basal layer and rete ridges. The images also illustrate that dermis integrity is preserved for 7 days.
More about Genoskin:
Genoskin specializes in procuring and processing high-quality, ethically sourced human tissues from consenting donors, ensuring researchers have access to a diverse range of tissues for their studies.
They provides a unique range of human skin platforms for reliable first-in-human testing purposes. As opposed to animal skin or engineered models, all our models only contain real human skin that is kept alive for 7 days after surgery, thanks to our proprietary technology. This approach allows for a full week of testing opportunities on all the types of cells and appendages of real, live human skin – simultaneously.
More about Novabiosis:
Novabiosis offers both fresh and frozen full thickness human tissues. It focuses on cryopreservation and viability optimization of native human tissues, providing researchers with well-preserved tissues suitable for a variety of research applications.
This high-quality skin tissue, recovered from abdomen, thighs, or lower back; offers researchers an excellent substrate for studying wound healing, skin diseases, and dermatological treatments. With its intact structure and cellular composition, fresh full thickness skin from Novabiosis enables accurate in vitro modelling, allowing researchers to develop and test new therapies with enhanced precision.
Frequently Asked Questions
Native human tissues are obtained directly from human donors, preserving their original structure, cellular composition, and functionality. Reconstructed tissues, on the other hand, are engineered in vitro from human cells to replicate the structure and function of natural tissues. Both have specific applications, with native tissues being ideal for studying natural biological processes and reconstructed tissues for ethical and standardized testing.
All tissues are ethically sourced with proper donor consent, adhering to strict regulatory and ethical guidelines. Tissue sourcing ensures transparency, donor anonymity, and compliance with ethical standards such as GDPR for data privacy.
Genoskin’s skin models are designed to remain viable and functional for up to 7 days post-surgery, providing researchers with an extended experimental window for comprehensive studies.
NativeSkin® is versatile and can be used for:
- Topical drug testing
- Skin irritation and corrosion studies
- UV exposure impact assessments
- Cosmetic product testing and efficacy validation
Yes, HypoSkin® is the only model that includes all three layers of the skin—epidermis, dermis, and hypodermis—making it ideal for subcutaneous and intradermal injection studies, including vaccine development and injection site reaction analysis.
Genoskin models are shipped in temperature-controlled packaging and should be handled as per the specific protocols provided with each model. NativeSkin® models, for example, are ready-to-use upon delivery and come with detailed guidelines to ensure optimal results.
Yes, many of these models align with regulatory standards, including OECD Test Guidelines, making them suitable for use in regulatory toxicity testing, irritation studies, and sensitization research.
Absolutely. Genoskin’s human tissue models are a scientifically validated alternative to animal testing, providing human-relevant data while adhering to ethical research practices.
Our technical team can guide you in selecting the appropriate model based on your specific research needs. Whether you're testing topical formulations, conducting injection studies, or studying immune responses, we have the right solution for you.
You can contact Krishgen Biosystems via email or phone, and our team will assist you in selecting the right model, provide pricing details, and guide you through the ordering process.