Enzymes
At Krishgen Biosystems, we provide an extensive portfolio of enzymes for ADME and DMPK studies, specifically curated to enhance the precision and efficiency of your workflows. By partnering with industry leaders like BioIVT, Santa Cruz Biotechnology (SCBT), and Cayman Chemical, we bring together a comprehensive collection of CYP and non-CYP enzymes optimized for critical drug metabolism and toxicology applications.
Our value lies not just in the breadth of our portfolio but in our ability to deliver ready-to-use solutions, customizable offerings, and expert insights, helping you streamline your experiments, overcome bottlenecks, and accelerate discovery.
Applications of Our Enzyme Portfolio
- Drug metabolism and toxicology studies.
- Identification of metabolites and metabolic pathways.
- Screening for enzyme inhibition/induction.
- Mechanistic studies in drug safety and efficacy.
Key Advantages:
- Comprehensive range of CYP and Non-CYP enzymes
- Validated for predictive ADME studies
- Ready-to-use products save time and reduce variability in experiments
- Inventory availability for quicker deliveries
- Consistently high-quality products validated for research and regulatory compliance
- Efficient supply chain ensuring timely delivery and consistent cold chain maintenance
CYP Enzymes (Cytochrome P450)
Cytochrome P450 enzymes play a critical role in drug metabolism by catalysing Phase I reactions like oxidation, reduction, and hydrolysis.
• Recombinant CYP450 Isoforms (BioIVT)
• CYP450 Activity Assay Kits (Cayman)
• Microsomal CYP450 Fractions (BioIVT)
• CYP450 Antibodies (SCBT)
Non-CYP Enzymes
Non-CYP enzymes are critical for Phase II reactions, including conjugation and detoxification processes.
• UGT (UDP-glucuronosyltransferases) Enzymes (BioIVT)
• SULT (Sulfotransferases) Enzymes (Cayman)
• Aldehyde Oxidase and Monoamine Oxidase (Cayman)
Rat BACTOSOMES® Enzymes: An effective tool for in vitro models
Featured Products
Human and Animal Recombinant Enzymes (BACTOSOMES)
BACTOSOMES® enzymes are bacterial membranes containing recombinant cytochrome P450 (rCYP) enzymes. They are useful in test systems requiring high levels of individual enzymatic activities.
A comprehensive range of human CYPs co-expressed with human NADPH CYP-reductase with or without human cytochrome b5.
The CYPs are available with high or low levels of reductase relative to the CYP, allowing you to choose products that fit your assay.
High Reductase Bactosomes
exhibit higher activity but the time for which the reaction is linear is shorter;
Low Reductase Bactosomes
have a lower activity but the reaction is linear for longer.
BioIVT offers Bactosomes for the following species:
Explore BACTOSOMES and their benefits / applications for your ADME research.
- CYP Isoform-Specific Assay Kits
- FMO3 Activity Assay Kit
- Aldehyde Oxidase Activity Assay Kit
- CYP Inhibitors (Ketoconazole, Quinidine)
- Non-CYP Inhibitor (Disulfiram)
If you cannot find what you are looking for, our application support team can find it for you! Get in touch today.