Human AB Serum for CAR-T Research
RUO and GMP Human AB Serum for Cell and Gene Therapy Applications
BioIVT’s Human AB Serum is a high-quality, human-derived supplement designed for cell culture, cell therapy manufacturing, gene therapy research, and vaccine development. Sourced exclusively from healthy male AB donors, this serum offers low immunogenicity and consistent performance, making it ideal for cell expansion, differentiation, and therapeutic applications.
Key Benefits of BioIVT Human AB Serum
- High Consistency & Low Immunogenicity – Sourced exclusively from healthy male AB donors to minimize variability and immune response.
- Sterility & Safety Testing – Each lot is screened for sterility, mycoplasma, endotoxin levels, and viral contaminants.
- GMP-Grade Availability – Supports clinical and therapeutic applications with full regulatory compliance.
- Optimized for Cell Therapy – Used in CAR-T, stem cell expansion, and vaccine manufacturing.
Brand & Quality Assurance
BioIVT
BioIVT is a global leader in biological matrices and cell therapy reagents, supplying high-quality, ethically sourced human AB serum.
✔ Regulatory-Ready – GMP-certified production for clinical and biopharma applications.
✔ Stringent Donor Screening – Sourced from FDA-registered, IRB-approved donors with full traceability.
✔ Multiple Processing Options – Includes heat-inactivated and gamma-irradiated formats for different research needs.
✔ Batch-to-Batch Consistency – Each lot undergoes quality control and functional validation for reproducibility.
Explore Human AB Serum Customisation Options
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Why Use Human AB Serum in CAR-T Research?
✔ Rich in Essential Growth Factors & Cytokines – Supports T-cell expansion and maintenance, ensuring robust cell viability and proliferation.
✔ Consistent & Reproducible Culture Conditions – Minimizes variability compared to other sera, making it ideal for pharma, biotech, and academic research.
✔ Preserves T-Cell Fitness Better Than FBS or Artificial Supplements – Maintaining a less exhausted T-cell phenotype is crucial for long-lasting therapeutic efficacy. FBS (Fetal Bovine Serum) contains non-human proteins, which can alter T-cell metabolism and lead to immunogenic complications in clinical applications. Serum-free formulations may limit exhaustion but lack the physiological complexity of Human AB Serum, which helps sustain T-cell viability, cytotoxic activity, and functionality over prolonged culture.
✔ Minimizes Immunogenic Risk Compared to FBS or Animal-Derived Supplements – Unlike FBS or other non-human serum sources, which may introduce xeno-immunogenic responses, Human AB Serum is fully human-derived, making it more clinically relevant and reducing the risk of unwanted immune activation upon reinfusion.
✔ Enhances Transduction Efficiency – In viral-based gene modification (e.g., lentiviral or retroviral transduction of CAR constructs), Human AB Serum optimizes the transduction process, leading to higher CAR expression levels and improved therapeutic potency of the final CAR-T product.
- also create a section somewhere near the top section – add images from here https://bioivt.com/human-serum-ab – How Does BioIVT’s Human AB Serum Compare?
| Attribute | BioIVT | Competitor M | Competitor S | Locally Sourced |
| Manufacturing Process | Plasma-derived serum is defibrinated using bovine thrombin; off-the-clot serum is allowed to clot naturally. | Not specified. | Off the Clot only | Varies; may lack standardized processing. |
| Quality Grades Available | Research Use Only (RUO) and Good Manufacturing Practice (GMP) grades. | Not specified. | RUO Only | Typically lacks formal quality grading. |
| Viral Testing | Extensive testing at both donor and finished pool levels, including HIV, HBV, HCV, and others. | Donor units tested and found negative for required viral markers via FDA-approved methods (HBsAg, HIV-1, HIV-2, HCV, HIV-1Ag or HIV-1 NAT, ALT, and syphilis). | Not specified. | Testing protocols vary; may not be comprehensive. |
| Sterility | Sterile-filtered; mycoplasma and endotoxin tested. | Sterile-filtered; mycoplasma and endotoxin tested. | Sterile-filtered; mycoplasma and endotoxin tested. | Sterility standards vary; may not be consistently tested. |
| Heat Inactivation | Available | Available | Available | Varies; must be performed in-house |
| Regulatory Compliance | GMP-grade available for clinical applications. | Not specified. | Not specified. | Typically lacks GMP compliance; suitability for clinical use is uncertain. |
BioIVT’s research-grade Human AB Serum is widely used in preclinical cell culture applications, offering high growth factor content and batch consistency for research workflows.
📌 Applications:
✔ Mammalian Cell Culture & Expansion – Supports cell proliferation and differentiation.
✔ Vaccine & Bioprocessing Research – Used as a nutrient-rich supplement in cell-based assays.
✔ T Cell & PBMC Culture – Enhances immune cell activation and survival.
[🔗 View Research-Grade Human AB Serum]
Designed for cell therapy, gene therapy, and biopharmaceutical applications, BioIVT’s GMP-compliant Human AB Serum meets the highest regulatory standards.
📌 Applications:
✔ Cell Therapy Manufacturing – Used in CAR-T and stem cell therapy workflows.
✔ Gene Therapy Research – Ensures a human-derived environment for viral vector production.
✔ Biopharmaceutical & Vaccine Production – Supports bioprocessing in GMP environments.
📌 Quality Standards:
✔ Sterility & Mycoplasma-Free – Ensures contaminant-free performance.
✔ Endotoxin Levels <1.0 EU/mL – Meets strict quality requirements for clinical use.
✔ Regulatory Compliance – Supports IND and regulatory submissions.
[🔗 View GMP-Grade Human AB Serum]
Heat inactivation deactivates complement proteins, making the serum ideal for immune-sensitive cell culture applications.
📌 Applications:
✔ T Cell & PBMC Culture – Reduces non-specific immune activation.
✔ Hybridoma & Antibody Production – Ensures consistent monoclonal antibody generation.
✔ Stem Cell Differentiation – Supports controlled cell development.
[🔗 View Heat-Inactivated Human AB Serum]
Gamma irradiation ensures enhanced viral safety, making this serum ideal for regulatory-driven applications.
📌 Applications:
✔ Biopharmaceutical Manufacturing – Ensures sterility for GMP workflows.
✔ Advanced Therapy Research – Used in cell therapy and regenerative medicine.
✔ Exosome & Secretome Studies – Minimizes background contamination in exosome isolation.
[🔗 View Gamma-Irradiated Human AB Serum]