BioIVT ADMET Solutions
BioIVT offers a comprehensive range of ADMET products designed to support drug discovery and development. From in vitro ADME assays to toxicology testing solutions, our high-quality biological materials and services enable researchers to evaluate absorption, distribution, metabolism, excretion, and toxicity with accuracy and efficiency.
Diverse Range of Products
Stock in Mumbai
Quality
BioIVT is the worldwide leader of biological ADMET-products to life sciences and pharmaceutical companies.
As the leading provider of human and animal hepatocyte products, BioIVT offers high-quality cells with the most characterization and the largest lot sizes in the industry.
BioIVT Cells and Fractions have:
- Large lot sizes available
- Extensive inventory (in Mumbai and in the US)
- High viability and consistency
- Proprietary technologies for higher quality products
- Specialized test systems
- Supply chain infrastructure with Krishgen and BioIVT working together to ensure cold chain maintanence
Product Types Available
Tissue and Sub-cellular Fractions
Non-Traditional Sub-cellular Fractions
Cryopreserved Hepatocytes
Recombinant Cytochrome P450 Enzymes
Non-Cyp Recombinant Enzymes
Tissue Sub-Cellular Fractions
BioIVT produces subcellular fractions through the process of subcellular fractionation, which is the separation of cellular components. The initial step starts with the homogenization of tissue in an isotonic buffer to aid in the separation of the cellular components.
Through differential centrifugation, BioIVT can isolate purified organelle fractions including:
Used in western blotting, protein binding, enzyme assays and matrix controls to determine if enzyme activity is important for your study.
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Microsomes are valuable tools in drug discovery for studying the metabolism of your compounds.
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A diverse range of products derived from human liver, lung, kidney, intestine, and skin tissues.
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Used in drug development as predictive test systems to evaluate specific drug-metabolizing enzymes that are highly expressed in certain cellular compartments / organelles.
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Preparations from liver cells are used in drug development as predictive test systems to evaluate specific drug-metabolizing enzymes that are enriched in certain cellular compartments / organelles.
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BioIVT’s standard products feature fully-characterized subcellular fractions from the following toxicologically-relevant species:
Human
Rat/Mouse
Rabbit
Monkey
Mini Pig
Hamster
Guinea-Pig
Dog
Non-Traditional Sub-Cellular Fractions
BioIVT offers non-traditional sub-cellular fractions to support advanced drug metabolism and pharmacokinetic (DMPK) studies. These specialized fractions, from various species, enable researchers to investigate enzyme activity, metabolic stability, and reaction phenotyping with greater flexibility and precision.
Used in western blotting, protein binding, enzyme assays and matrix controls to determine if enzyme activity is important for your study.
Learn more
Microsomes are valuable tools in drug discovery for studying the metabolism of your compound
Learn more
Used in drug development as predictive test systems to evaluate specific drug-metabolizing enzymes that are highly expressed in certain cellular compartments / organelles.
Learn more
Cryopreserved Hepatocytes
Purified frozen liver cells that can be thawed and cultured in a lab. Hepatocytes are the main structural and functional parenchymal cells of the liver.
They make up approx. 80% of the liver, but only 60% of the total liver cells.
Hepatocytes express high levels of transporters and drug metabolizing enzymes (DMEs).
Select the Right Hepatocytes for Your Study
Which in vitro test system best suits my needs?
We offer a wide variety of hepatocyte test systems. We can provide immortalized or primary cells, fresh or cryopreserved, animal or human hepatocytes in the format of your choice. We have individual donor and pooled donors, suspension and plateable cells, and can even plate the hepatocytes for you.
Choose quality human cryoplateable hepatocytes from BioIVT.
For short-term assays, individual, LIVERPOOL® and Cryostax® human cryosuspension hepatocytes are available.
Freshly isolated hepatocytes are offered from human, rat, dog, monkey and mouse.
For long-term assays, check out the extensive offering of animal cryoplateable hepatocytes.
For short-term in vitro studies, view our extensive animal cryosuspension inventory of preclinical species.
Hepatocytes from the immortalized Fa2N-4 cell line maintain near-normal morphology in culture, suitable for induction screening and lysosomal trapping assays.
BioIVT offers an extensive catalog of recombinant CYPs and purified enzymes, including all the CYPs typically investigated in drug discovery programs.
A comprehensive range of human CYPs co-expressed with human NADPH CYP-reductase with or without human cytochrome b5. The CYPs are available with high or low levels of reductase relative to the CYP, allowing you to choose products that fit your assay.
High Reductase Bactosomes exhibit higher activity but the time for which the reaction is linear is shorter;
Low Reductase Bactosomes have a lower activity but the reaction is linear for longer.
BioIVT also has introduced ranges of animal equivalents for use in the development of veterinary medicines. These include:
Recombinant CYP BACTOSOMES®: Versatile Formats for Many ADME Applications
Recombinant cytochrome P450 (rCYP) enzymes are commonly used in ADME-Tox studies as in vitro tools, mostly for reaction phenotyping, enzyme inhibition screening, clearance and metabolite ID.
Non-CYP Recombinant Enzymes:
BioIVT provides non-CYP recombinant enzymes for reliable in vitro studies of drug metabolism and biotransformation. These high-quality enzymes support research on phase I and phase II metabolic pathways, enabling precise evaluation of compound stability, metabolite profiling, and potential drug-drug interactions.
Featured Products
Cell Selection, Handling & Media Tips to Get the Best Results from Your Hepatocyte Assays
Stock Availability in the Mumbai Warehouse
This stock may have discrepancies as it is not updated in real time. Please get in touch with our team before placing your final order.
The above stock represents ADME tissues and enzymes available with us in Mumbai. In case you are looking for plasma, sera or other CGT products, please view our CGT page here.
More About In Vitro Hepatocyte Models
Improving In Vivo Predictions from In Vitro Hepatocyte Models
Abstract: In both in vitro systems and in vivo, it is the unbound intracellular concentration (ICC) that is the driving force for processes that occur inside the hepatocyte. Achievement of an in vivo relevant ICC requires a polarized whole-cell system that integrates uptake into the hepatocyte, metabolism, and efflux (basolateral and canalicular) from the hepatocyte. Extensive protein binding can limit the uptake of many drugs, however for some drugs the estimation of intracellular concentration, and hepatic clearance cannot be correctly predicted based on the free (unbound) drug concentration. Additionally, studies have shown that transporters can be upregulated similar to metabolic proteins, resulting in increased uptake and/or efflux. Use of polarized whole-cell models and optimized culture conditions for in vitro systems may improve predictions of a drug’s in vivo properties and effects.
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