CRISPR tools
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology has revolutionized genome editing, enabling precise modifications in DNA sequences to study gene functions, develop therapies, and improve agricultural traits. Our curated selection of CRISPR/Cas9 tools encompasses a wide array of products and services designed to facilitate cutting-edge research and applications.
Key Benefits of Our CRISPR/Cas9 Tools
✔ Comprehensive Product Range – From ready-to-use cell lines to detection kits, our offerings cover all aspects of CRISPR/Cas9 research.
✔ High Efficiency and Specificity – Our tools are optimized for precise targeting with minimal off-target effects.
✔ Customizable Solutions – Tailor-made products and services to meet specific research needs.
✔ Expert Technical Support – Access to knowledgeable professionals to assist with experimental design and troubleshooting.
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Comprehensive Tools for CRISPR / Cas9
ABM provides a wide range of ready-to-use CRISPR Knockout Cell Lines and Cas9 Expressing Cell Lines, making genome editing more accessible without requiring in-house CRISPR modification.
Available Products:
- CRISPR Knockout Cell Line Library – Over 5,000 knockout models for human and mouse genes.
- Stable Cas9 Expressing Cell Lines – Cell lines pre-engineered to express Cas9, allowing easy CRISPR-mediated editing with gRNAs.
- CRISPR Knock-in Repair Templates – Designed for precise homology-directed repair (HDR) modifications, allowing transgene insertion or targeted mutations.
Cas9 proteins and RNP complexes allow for direct CRISPR editing without plasmid transfection, reducing off-target effects and eliminating concerns about unwanted gene integration.
Available Products:
- Wild-Type Cas9 Proteins – Standard Cas9 enzyme for DNA cleavage.
- Nickase Cas9 (Cas9n) – Generates single-strand breaks to reduce off-target effects.
- High-Fidelity Cas9 (HiFi Cas9) – Engineered for greater specificity and fewer unintended mutations.
- Cas9 Ribonucleoproteins (Cas9 RNPs) – Cas9 pre-complexed with guide RNA, enabling rapid, transient genome editing.
Lentiviral vectors and other delivery systems are essential for efficient CRISPR gene editing, particularly in difficult-to-transfect cell types. Gentarget and ABM provide high-efficiency CRISPR delivery tools.
Available Products:
- Lentiviral gRNA Vectors – Pre-designed vectors for stable gene targeting and integration.
- Non-Integrating Lentiviral CRISPR Systems – Ideal for transient genome editing without genome insertion.
- CRISPR Plasmids for Direct Transfection – gRNA vectors designed for electroporation or lipofection-based delivery.
- RNP-Based CRISPR Systems – Eliminates viral and plasmid components, ensuring cleaner editing results.
CRISPR activation (CRISPRa) and interference (CRISPRi) use dead Cas9 (dCas9) fused with transcriptional activators or repressors to modulate gene expression without introducing double-stranded breaks (DSBs). For gene activation and inhibition, we offer:
Available Products:
- dCas9-VP64 & dCas9-SAM Activators – Drive strong gene upregulation for functional studies.
- dCas9-KRAB Repressors – Suppresses gene expression without genome modification.
- Lentiviral CRISPRa/i Constructs – Ready-to-use delivery for long-term stable activation/inhibition.
- Custom CRISPRa/i Services – Tailor-made solutions for specific target genes.
CRISPR Knock-in Repair Templates enable precise genome modifications, including point mutations, in-frame fusion tags, and large transgene insertions.
Available Products:
- Single-Stranded Oligo Repair Templates (ssODN) – Small edits up to 50bp for SNP corrections.
- Double-Stranded Knock-in Templates – For larger transgene insertions into specific loci.
- Custom CRISPR Knock-in Services – Fully designed HDR templates with validation.
Validating CRISPR edits is crucial to ensure on-target efficiency and minimal off-target effects. ABM offers detection tools to streamline post-editing analysis.
Available Products:
- Screen It™ CRISPR-Cas9 Cleavage Detection Kit – Detects mutations induced by CRISPR editing using PCR-based methods.
- Next-Gen Sequencing (NGS) CRISPR Validation – Deep sequencing-based analysis for pinpoint accuracy.
- T7E1 Assay Kits – Mutation detection through enzymatic mismatch cleavage.
🔗 View CRISPR Cleavage Detection Kits
📞 Need Assistance? Contact Us!
✔ Expert Support: Our specialists help with CRISPR design, knockout validation, and troubleshooting.
✔ Custom Solutions: Tailor-made CRISPR gRNA, plasmids, and repair templates for unique projects.
✔ Regulatory Documentation: All products include CoA, MSDS, and validation reports for reproducibility.